Voor de beste ervaring schakelt u JavaScript in en gebruikt u een moderne browser!

Dhr. dr. H.J. (Harm) Krugers

Faculteit der Natuurwetenschappen, Wiskunde en Informatica
Swammerdam Institute for Life Sciences
Fotograaf: Harm Krugers

  • Science Park 904
  • Kamernummer:C3.270
  • Postbus 94246
    1090 GE Amsterdam
  • Publicaties


    • Lesuis, S. L., Lucassen, P. J., & Krugers, H. J. (2021). Early life stress amplifies fear responses and hippocampal synaptic potentiation in the APPswe/PS1dE9 Alzheimer mouse model. Neuroscience, 454, 151-161. https://doi.org/10.1016/j.neuroscience.2019.07.012 [details]
    • Sanguino-Gómez, J., Buurstede, J. C., Abiega, O., Fitzsimons, C. P., Lucassen, P. J., Eggen, B. J., Lesuis, S. L., Meijer, O. C., & Krugers, H. J. (2021). An emerging role for microglia in stress-effects on memory. European Journal of Neuroscience. https://doi.org/10.1111/ejn.15188


    • Genzel, L., Adan, R., Berns, A., van den Beucken, J. J. J. P., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A-M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020). How the COVID-19 pandemic highlights the necessity of animal research. Current Biology, 30(18), R1014-R1018. https://doi.org/10.1016/j.cub.2020.08.030
    • Genzel, L., Adan, R., Berns, A., van den Beucken, J. J. J. P., Blokland, A., Boddeke, E. H. W. G. M., Bogers, W. M., Bontrop, R., Bulthuis, R., Bousema, T., Clevers, H., Coenen, T. C. J. J., van Dam, A-M., Deen, P. M. T., van Dijk, K. W., Eggen, B. J. L., Elgersma, Y., Erdogan, I., Englitz, B., ... Homberg, J. R. (2020). How the COVID-19 pandemic highlights the necessity of animal research: correction. Current Biology, 30(21), 4328. https://doi.org/10.1016/j.cub.2020.10.033
    • Krugers, H., & Baeken, C. (2020). Signaaltransductie, receptoren en hersenstimulatie. In O. van den Heuvel, Y. van der Werf, B. Schmand, & B. Sabbe (Eds.), Leerboek neurowetenschappen voor de klinische psychiatrie (pp. 82-87). Amsterdam: Boom. [details]
    • Krugers, H., Kessels, H., & Lucassen, P. (2020). Plasticiteit in de hersenen; synaptische plasticiteit en adulte neurogenese. In O. van den Heuvel, Y. van den Werf, B. Schmand, & B. Sabbe (Eds.), Leerboek neurowetenschappen voor de klinische psychiatrie (pp. 52-58). Boom. [details]
    • Lesuis, S. L., Timmermans, W., Lucassen, P. J., Hoogenraad, C. C., & Krugers, H. J. (2020). Glucocorticoid and β-adrenergic regulation of hippocampal dendritic spines. Journal of Neuroendocrinology, 32(1), [e12811]. https://doi.org/10.1111/jne.12811 [details]
    • Popma, A., & Krugers, H. (2020). Frustratie bij uitblijven van beloning. In O. van den Heuvel, Y. van der Werf, B. Schmand, & B. Sabbe (Eds.), Leerboek neurowetenschappen voor de klinische psychiatrie (pp. 185-190). Amsterdam: Boom. [details]




    • Kanatsou, S., Karst, H., Kortesidou, D., van den Akker, R. A., den Blaauwen, J., Harris, A. P., ... Joëls, M. (2017). Overexpression of Mineralocorticoid Receptors in the Mouse Forebrain Partly Alleviates the Effects of Chronic Early Life Stress on Spatial Memory, Neurogenesis and Synaptic Function in the Dentate Gyrus. Frontiers in Cellular Neuroscience, 11, [132]. https://doi.org/10.3389/fncel.2017.00132 [details]
    • Krugers, H. J., Arp, J. M., Xiong, H., Kanatsou, S., Lesuis, S. L., Korosi, A., ... Lucassen, P. J. (2017). Early life adversity: Lasting consequences for emotional learning. Neurobiology of Stress, 6, 14-21. https://doi.org/10.1016/j.ynstr.2016.11.005 [details]
    • Lesuis, S. L., van Hoek, B. A. C. E., Lucassen, P. J., & Krugers, H. J. (2017). Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe/PS1dE9 mice at middle age. Neurobiology of Learning and Memory, 144, 27-35. https://doi.org/10.1016/j.nlm.2017.05.016 [details]
    • Lissek, T., Adams, M., Adelman, J., Ahissar, E., Akaaboune, M., Akil, H., ... Hasan, M. T. (2017). Building Bridges through Science. Neuron, 96(4), 730-735. https://doi.org/10.1016/j.neuron.2017.09.028 [details]
    • Lucassen, P. J., Korosi, A., Krugers, H. J., & Oomen, C. A. (2017). Early life stress- and sex-dependent effects on hippocampal neurogenesis. In G. Fink (Ed.), Stress: Neuroendocrinology and Neurobiology [135–146] (Handbook of Stress; Vol. 2). Academic Press. https://doi.org/10.1016/B978-0-12-802175-0.00013-9 [details]
    • Mikasova, L., Xiong, H., Kerkhofs, A., Bouchet, D., Krugers, H. J., & Groc, L. (2017). Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling. Scientific Reports, 7, [8053]. https://doi.org/10.1038/s41598-017-08695-3 [details]
    • Vogel, S., Klumpers, F., Navarro Schröder, T., Oplaat, K. T., Krugers, H. J., Oitzl, M. S., ... Fernández, G. (2017). Stress Induces a Shift Towards Striatum-Dependent Stimulus-Response Learning via the Mineralocorticoid Receptor. Neuropsychopharmacology, 42(6), 1262–1271. https://doi.org/10.1038/npp.2016.262 [details]


    • Arp, J. M., ter Horst, J. P., Loi, M., den Blaauwen, J., Bangert, E., Fernández, G., Joëls, M., Oitzl, M. S., & Krugers, H. J. (2016). Blocking glucocorticoid receptors at adolescent age prevents enhanced freezing between repeated cue-exposures after conditioned fear in adult mice raised under chronic early life stress. Neurobiology of Learning and Memory, 133, 30-38. https://doi.org/10.1016/j.nlm.2016.05.009 [details]
    • Derks, N. A. V., Krugers, H. J., Hoogenraad, C. C., Joëls, M., & Sarabdjitsingh, R. A. (2016). Effects of Early Life Stress on Synaptic Plasticity in the Developing Hippocampus of Male and Female Rats. PLoS ONE, 11(10), [e0164551]. https://doi.org/10.1371/journal.pone.0164551 [details]
    • Kanatsou, S., Ter Horst, J. P., Harris, A. P., Seckl, J. R., Krugers, H. J., & Joëls, M. (2016). Effects of Mineralocorticoid Receptor Overexpression on Anxiety and Memory after Early Life Stress in Female Mice. Frontiers in Behavioral Neuroscience, 9, [374]. https://doi.org/10.3389/fnbeh.2015.00374 [details]
    • Lesuis, S. L., Maurin, H., Borghgraef, P., Lucassen, P. J., Van Leuven, F., & Krugers, H. J. (2016). Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease. Oncotarget, 7(26), 39118-39135. https://doi.org/10.18632/oncotarget.9776 [details]
    • Xiong, H., Cassé, F., Zhou, M., Xiong, Z. Q., Joels, M., Martin, S., & Krugers, H. J. (2016). Interactions between N-Ethylmaleimide-sensitive factor and GluA2 contribute to effects of glucocorticoid hormones on AMPA receptor function in the rodent hippocampus. Hippocampus, 26(7), 848-856. https://doi.org/10.1002/hipo.22567 [details]



    • Arp, J. M., ter Horst, J. P., Kanatsou, S., Fernández, G., Joëls, M., Krugers, H. J., & Oitzl, M. S. (2014). Mineralocorticoid receptors guide spatial and stimulus-response learning in mice. PLoS ONE, 9(1), e86236. https://doi.org/10.1371/journal.pone.0086236 [details]
    • Krugers, H., & Joëls, M. (2014). Long-lasting Consequences of Early Life Stress on Brain Structure, Emotion and Cognition. In C. M. Pariante, & M. D. Lapiz-Bluhm (Eds.), Behavioral neurobiology of stress-related disorders (pp. 81-92). (Current topics in behavioral neurosciences; No. 18). Heidelberg: Springer. https://doi.org/10.1007/7854_2014_289 [details]
    • Maccari, S., Krugers, H. J., Morley-Fletcher, S., Szyf, M., & Brunton, P. J. (2014). The consequences of early life adversity: neurobiological, behavioural and epigenetic adaptations. Journal of Neuroendocrinology, 26(10), 707-723. https://doi.org/10.1111/jne.12175 [details]
    • Sarabdjitsingh, R. A., Zhou, M., Yau, J. L. W., Webster, S. P., Walker, B. R., Seckl, J. R., ... Krugers, H. J. (2014). Inhibiting 11β-hydroxysteroid dehydrogenase type 1 prevents stress effects on hippocampal synaptic plasticity and impairs contextual fear conditioning. Neuropharmacology, 81, 231-236. https://doi.org/10.1016/j.neuropharm.2014.01.042 [details]
    • Schouten, M., De Luca, G. M. R., Alatriste González, D. K., de Jong, B. E., Timmermans, W., Xiong, H., ... Fitzsimons, C. P. (2014). Imaging dendritic spines of rat primary hippocampal neurons using structured illumination microscopy. Journal of Visualized Experiments, 87, e51276. https://doi.org/10.3791/51276 [details]
    • Vermetten, E., Zhohar, J., & Krugers, H. J. (2014). Pharmacotherapy in the aftermath of trauma; opportunities in the 'golden hours'. Current psychiatry reports, 16(7), 455. https://doi.org/10.1007/s11920-014-0455-y [details]
    • Wang, Q., Verweij, E. W. E., Krugers, H. J., Joels, M., Swaab, D. F., & Lucassen, P. J. (2014). Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients. Brain Structure and Function, 219(5), 1615-1626. https://doi.org/10.1007/s00429-013-0589-4 [details]



    • Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J. (2012). Early-life stress mediated modulation of adult neurogenesis and behavior. Behavioural Brain Research, 227(2), 400-409. https://doi.org/10.1016/j.bbr.2011.07.037 [details]
    • Krugers, H. J., Karst, H., & Joëls, M. (2012). Interactions between noradrenaline and corticosteroids in the brain: from electrical activity to cognitive performance. Frontiers in Cellular Neuroscience, 6, [15]. https://doi.org/10.3389/fncel.2012.00015 [details]
    • Krugers, H. J., Oomen, C. A., Gumbs, M., Li, M., Velzing, E. H., Joëls, M., & Lucassen, P. J. (2012). Maternal deprivation and dendritic complexity in the basolateral amygdala. Neuropharmacology, 62(1), 534-537. https://doi.org/10.1016/j.neuropharm.2011.09.022 [details]
    • Pillai, A. G., de Jong, D., Kanatsou, S., Krugers, H., Knapman, A., Heinzmann, J-M., ... Touma, C. (2012). Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity. PLoS ONE, e0038971. https://doi.org/10.1371/journal.pone.0038971 [details]
    • Ramakers, G. J. A., Wolfer, D., Rosenberger, G., Kuchenbecker, K., Kreienkamp, H. J., Prange-Kiel, J., ... Kutsche, K. (2012). Dysregulation of Rho GTPases in the alphaPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits. Human Molecular Genetics, 21(2), 268-286. https://doi.org/10.1093/hmg/ddr457 [details]
    • Zhou, M., Hoogenraad, C. C., Joëls, M., & Krugers, H. J. (2012). Combined β-adrenergic and corticosteroid receptor activation regulates AMPA receptor function in hippocampal neurons. Journal of Psychopharmacology, 26(4), 516-524. https://doi.org/10.1177/0269881111424930 [details]
    • van Hasselt, F. N., Boudewijns, Z. S. R. M., van der Knaap, N. J. F., Krugers, H. J., & Joëls, M. (2012). Maternal care received by individual pups correlates with adult CA1 dendritic morphology and synaptic plasticity in a sex-dependent manner. Journal of Neuroendocrinology, 24, 331-340. https://doi.org/10.1111/j.1365-2826.2011.02233.x [details]
    • van Hasselt, F. N., Cornelisse, S., Zhang, T. Y., Meaney, M. J., Velzing, E. H., Krugers, H. J., & Joëls, M. (2012). Adult hippocampal glucocorticoid receptor expression and dentate synaptic plasticity correlate with maternal care received by individuals early in life. Hippocampus, 22(2), 255-266. https://doi.org/10.1002/hipo.20892 [details]
    • van Hasselt, F. N., Tieskens, J. M., Trezza, V., Krugers, H. J., Vanderschuren, L. J. M. J., & Joëls, M. (2012). Within-litter variation in maternal care received by individual pups correlates with adolescent social play behavior in male rats. Physiology & behavior, 106(5), 701-706. https://doi.org/10.1016/j.physbeh.2011.12.007 [details]
    • van Hasselt, F. N., Visser, L., Tieskens, J. M., Cornelisse, S., Baars, A. M., Lavrijsen, M., ... Joëls, M. (2012). Individual variations in maternal care early in life correlate with later life decision-making and c-fos expression in prefrontal subregions of rats. PLoS ONE, 7(5), [e37820]. https://doi.org/10.1371/journal.pone.0037820 [details]



    • Krugers, H. J., Hoogenraad, C. C., & Groc, L. (2010). Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory. Nature Reviews Neuroscience, 11(10), 675-681. https://doi.org/10.1038/nrn2913 [details]
    • Krugers, H. J., Lucassen, P. J., Karst, H., & Joëls, M. (2010). Chronic stress effects on hippocampal structure and synaptic function: relevance for depression and normalization by anti-glucocorticoid treatment. Frontiers in Synaptic Neuroscience, 2(24), 24. https://doi.org/10.3389/fnsyn.2010.00024 [details]
    • Oomen, C. A., Soeters, H., Audureau, N., Vermunt, L., van Hasselt, F. N., Manders, E. M. M., ... Krugers, H. (2010). Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. The Journal of Neuroscience, 30(19), 6635-6645. https://doi.org/10.1523/JNEUROSCI.0247-10.2010 [details]
    • Zhou, M., Bakker, E. H. M., Velzing, E., Berger, S., Oitzl, M., Joëls, M., & Krugers, H. J. (2010). Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice. Neurobiology of Learning and Memory, 94(4), 530-537. https://doi.org/10.1016/j.nlm.2010.09.005 [details]


    • Alfarez, D. N., De Simoni, A., Velzing, E. H., Bracey, E., Joëls, M., Edwards, F. A., & Krugers, H. J. (2009). Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons. Hippocampus, 19(9), 828-836. https://doi.org/10.1002/hipo.20566 [details]
    • Bagot, R. C., van Hasselt, F. N., Champagne, D. L., Meaney, M. J., Krugers, H. J., & Joëls, M. (2009). Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus. Neurobiology of Learning and Memory, 92(3), 292-300. https://doi.org/10.1016/j.nlm.2009.03.004 [details]
    • Jaworski, J., Kapitein, L. C., Montenegro Gouveia, S., Dortland, B. R., Wulf, P. S., Grigoriev, I., ... Hoogenraad, C. C. (2009). Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron, 61(1), 85-100. https://doi.org/10.1016/j.neuron.2008.11.013 [details]
    • Joëls, M., Karst, H., Krugers, H. J., & de Kloet, R. (2009). Corticosteroid Actions on Electrical Activity in the Limbic Brain. In D. W. Pfaff, A. P. Arnold, A. M. Etgen, S. E. Fahrbach, & R. T. Rubin (Eds.), Hormones, brain and behavior. - 2nd ed. - Vol. 3: Cellular and molecular mechanisms of hormone actions on behavior (pp. 1397-1420). Amsterdam: Academic Press. https://doi.org/10.1016/B978-008088783-8.00042-5 [details]
    • Joëls, M., Krugers, H. J., Lucassen, P. J., & Karst, H. (2009). Corticosteroid effects on cellular physiology of limbic cells. Brain Research, 1293, 91-100. https://doi.org/10.1016/j.brainres.2009.03.036 [details]
    • Krugers, H. J., & Hoogenraad, C. C. (2009). Hormonal regulation of AMPA receptor trafficking and memory formation. Frontiers in Synaptic Neuroscience, 1, [2]. https://doi.org/10.3389/neuro.19.002.2009 [details]
    • Martin, S., Henley, J. M., Holman, D., Zhou, M., Wiegert, O., van Spronsen, M., ... Krugers, H. J. (2009). Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity. PLoS ONE, 4(3), [e4714]. https://doi.org/10.1371/journal.pone.0004714 [details]
    • Oomen, C. A., Girardi, C. E. N., Cahyadi, R., Verbeek, E. C., Krugers, H., Joëls, M., & Lucassen, P. J. (2009). Opposite effects of early maternal deprivation on neurogenesis in male versus female rats. PLoS ONE, 4(1), e3675. https://doi.org/10.1371/journal.pone.0003675 [details]
    • Pu, Z., Krugers, H. J., & Joëls, M. (2009). Beta-adrenergic facilitation of synaptic plasticity in the rat basolateral amygdala in vitro is gradually reversed by corticosterone. Learning & Memory, 16(2), 155-160. https://doi.org/10.1101/lm.1272409 [details]
    • Zhou, M., Conboy, L., Sandi, C., Joëls, M., & Krugers, H. J. (2009). Fear conditioning enhances spontaneous AMPA receptor-mediated synaptic transmission in mouse hippocampal CA1 area. European Journal of Neuroscience, 30(8), 1559-1564. https://doi.org/10.1111/j.1460-9568.2009.06951.x [details]


    • Alfarez, D. N., Karst, H., Velzing, E. H., Joëls, M., & Krugers, H. J. (2008). Opposite effects of glucocorticoid receptor activation on hippocampal CA1 dendritic complexity in chronically stressed and handled animals. Hippocampus, 18(1), 20-28. https://doi.org/10.1002/hipo.20360 [details]
    • Champagne, D. L., Bagot, R. C., van Hasselt, F., Ramakers, G., Meany, M. J., de Kloet, E. R., ... Krugers, H. (2008). Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. The Journal of Neuroscience, 28(23), 6037-6045. https://doi.org/10.1523/JNEUROSCI.0526-08.2008 [details]
    • Krugers, H. (2008). Stress en plasticiteit van de hersenen: effecten op functie en structuur. In J. Vandermeulen, M. Derix, & C. Lafosse (Eds.), Neuroplasticiteit (pp. 111-124, 199-201). Amsterdam: Boom. [details]


    • Lucassen, P. J., Lesuis, S. L., Hoeijmakers, L., Yam, K. Y., Fitzsimons, C. P., Korosi, A., & Krugers, H. (2019). Brain plasticity in relation to (early life) stress, nutrition and dementia. Journal of Neural Transmission, 126(11), 1561-1562.


    • Loi, M., Sarabdjitsingh, R. A., Tsouli, A., Trinh, S., Arp, M., Krugers, H. J., Karst, H., van den Bos, R., & Joëls, M. (2017). Transient Prepubertal Mifepristone Treatment Normalizes Deficits in Contextual Memory and Neuronal Activity of Adult Male Rats Exposed to Maternal Deprivation. eNeuro, 4(5), [e0253]. https://doi.org/10.1523/ENEURO.0253-17.2017 [details]


    • Joëls, M., Fernandez, G., Krugers, H., & Karst, H. (2015). Brain mineralocorticoid receptor: The other one. Psychoneuroendocrinology, 61, 13. https://doi.org/10.1016/j.psyneuen.2015.07.423
    • Kanatsou, S., Fearey, B. C., Kuil, L. E., Lucassen, P. J., Harris, A. P., Seckl, J. R., Krugers, H., & Joels, M. (2015). Correction: Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity. PLoS ONE, 10(12), [e0145706]. https://doi.org/10.1371/journal.pone.0145706


    • Krugers, H. J. (2016-). board member, Amsterdam Brain and Cognition UvA.
    • Krugers, H. J. (2016-). Board Secretary of the Dutch Neurofederation, Dutch Neurodederation.
    • Krugers, H. J. (2016-). Board member of Stichting voor Interdisciplinair gedragsonderzoek (SIGO, Stichting voor Interdisciplinair gedragsonderzoek (SIGO)..
    • Krugers, H. J. (2013-). Board member European Brain and Behaviour Society (EBBS), European Brain and Behaviour Society.


    • Rouw, R. (speaker) & Krugers, H. J. (speaker) (21-11-2016). Zie je wat je ziet?, Congrescentrum Corpus.
    • Krugers, H. J. (speaker) (18-9-2016). Understanding fear memory formation: from synapses to targeting fear., ECNP Conference, Vienna.
    • Krugers, H. J. (speaker) (2-7-2016). Stress, synapses and memory, EMCCS meeting, Copenhagen.
    • Krugers, H. J. (speaker) (9-6-2016). Early Life Adversity moderates emotional memory processing, Dutch Neuroscience Meeting , Lunteren.
    • Krugers, H. J. (speaker) (24-5-2016). Stress and memory; from synapses to Alzheimer’s Disease, Stress and memory; from synapses to Alzheimer’s Disease, Dusseldorf.
    • Krugers, H. J. (speaker) (10-5-2016). Zie je werkelijk wat je ziet ?, Corpus.
    • Krugers, H. J. (speaker) (11-3-2016). Blood brain barrier clearance of Aβ peptides in Alzheimer’s disease Models, International Sichting voor Alzheimer Onderzoek, , Utrecht.
    • Krugers, H. J. (speaker) (16-2-2016). Molecular mechanisms underlying fear memories: importance to target fear., Molecular mechanisms underlying fear memories: importance to target fear., Bilbao.
    • Krugers, H. J. (speaker) (4-2-2016). Individual variation in memory formation, Social Brain Lab, Amsterdam.
    This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library or the Pure staff of your faculty / institute. Log in to Pure to edit your publications. Log in to Personal Page Publication Selection tool to manage the visibility of your publications on this list.
  • Nevenwerkzaamheden
    • Geen nevenwerkzaamheden